Urban axis in Middle East Political Dynamics

We learned long ago that there existed a whole plane of reality undetected by the press and other governments, scientists, as well as sojournors in areas where they remain blissfully ignorant of what's happening around them. The fastest way to reveal this unknown plane is to draw lines connecting all regional cities with all regional cities. For example, we can talk of the Damascus/Cairo axis, or the Kabul/Baghdad one. Smaller cities connected by road can also exhibit hidden but extremely potent energies for trade and development. For example, we can speak of the Jerusalem/Tel Aviv axis, or the one that exists between Ma'an, Jordon, to Tabuk, Saudi Arabia. Not all axis are relevant or potent, but all do exist. There are always people from Beirut living in, say, Aleppo (Haleb), and always people from Haleb living in Beirut. Furthermore, the schoolbooks explicitly bring out these hidden axis by study of geography, economics, or history. Remember, these are factors and events falling outside the purlieu of central governments The actors are often businessmen, teachers or local councils or deputy ministers. All do their thing below the radar of even the best media or intelligence outfit.
What urban axis interest you? Please post with explanation or just a question.